Title : [Effect of vitamin A on the endogenous synthesis and system of N-nitrosodimethylamine detoxication in the rat liver].

Pub. Date : 1987

PMID : 3691397






2 Functional Relationships(s)
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1 The administration of N-nitrosodimethylamine (NDMA) and its endogenic synthesis from amidopyrine and sodium nitrite decreases in the liver the level of reduced glutathione, ascorbic acid, glutathione reductase and glutathione-S-transferase activities, the accumulation of oxidized glutathione as well as the damage of DNA. Dimethylnitrosamine hematopoietic prostaglandin D synthase Rattus norvegicus
2 The administration of N-nitrosodimethylamine (NDMA) and its endogenic synthesis from amidopyrine and sodium nitrite decreases in the liver the level of reduced glutathione, ascorbic acid, glutathione reductase and glutathione-S-transferase activities, the accumulation of oxidized glutathione as well as the damage of DNA. Dimethylnitrosamine hematopoietic prostaglandin D synthase Rattus norvegicus