Title : Suppression of hemostatic system activation by oral anticoagulants in the blood of patients with thrombotic diatheses.

Pub. Date : 1987 Dec

PMID : 3680513






2 Functional Relationships(s)
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1 The mean F1 + 2 level in antithrombin-deficient individuals on warfarin was significantly elevated (mean = 0.714 nM) as compared with that in anticoagulated subjects with protein C deficiency (mean = 0.205 nM) or in those without an inherited thrombotic disorder (P less than 0.01) at equivalent levels of intensity of oral anticoagulation. Warfarin serpin family C member 1 Homo sapiens
2 We therefore conclude that the effect of warfarin on hemostatic system activation is modulated by the endogenous heparan sulfate-antithrombin mechanism. Warfarin serpin family C member 1 Homo sapiens