Title : Correlation of rat pituitary prolactin messenger ribonucleic acid and hormone content with serum levels during the estrogen-induced surge.

Pub. Date : 1987 Dec

PMID : 3678136






10 Functional Relationships(s)
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1 The model of the serum PRL surge generated in the ovariectomized rat after estradiol benzoate (EB) treatment was used to study the relationship between serum and pituitary PRL levels and pituitary PRL mRNA levels. estradiol 3-benzoate prolactin Rattus norvegicus
2 The model of the serum PRL surge generated in the ovariectomized rat after estradiol benzoate (EB) treatment was used to study the relationship between serum and pituitary PRL levels and pituitary PRL mRNA levels. estradiol 3-benzoate prolactin Rattus norvegicus
3 At other times, serum PRL levels in the EB group were the same as control values. estradiol 3-benzoate prolactin Rattus norvegicus
4 EB treatment also elicited a marked increase in pituitary PRL content at all time periods examined except during (1600 and 2000 h) and after the PRL surge (2400 h on day 3) when there was a significant reduction in stored pituitary PRL. estradiol 3-benzoate prolactin Rattus norvegicus
5 EB treatment also elicited a marked increase in pituitary PRL content at all time periods examined except during (1600 and 2000 h) and after the PRL surge (2400 h on day 3) when there was a significant reduction in stored pituitary PRL. estradiol 3-benzoate prolactin Rattus norvegicus
6 EB treatment also elicited a marked increase in pituitary PRL content at all time periods examined except during (1600 and 2000 h) and after the PRL surge (2400 h on day 3) when there was a significant reduction in stored pituitary PRL. estradiol 3-benzoate prolactin Rattus norvegicus
7 The pituitary PRL mRNA content in the EB-treated group was significantly elevated (4- to 6-fold) over control levels throughout the study. estradiol 3-benzoate prolactin Rattus norvegicus
8 Furthermore, PRL mRNA levels in EB-treated rats were significantly higher at 2000 and 2400 h on day 3 than at other time periods. estradiol 3-benzoate prolactin Rattus norvegicus
9 Furthermore, the facts that serum PRL levels were elevated only at certain times (1200-2000 h on day 3) while PRL mRNA content was increased at all times in the EB-treated rats suggest a differential regulation between PRL release and biosynthesis. estradiol 3-benzoate prolactin Rattus norvegicus
10 Furthermore, the facts that serum PRL levels were elevated only at certain times (1200-2000 h on day 3) while PRL mRNA content was increased at all times in the EB-treated rats suggest a differential regulation between PRL release and biosynthesis. estradiol 3-benzoate prolactin Rattus norvegicus