Title : Serum protein binding of phenytoin, diazepam and propranolol in age-related decrease in renal function.

Pub. Date : 1987

PMID : 3674731






3 Functional Relationships(s)
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1 The free fraction of phenytoin correlated negatively with the serum albumin concentration, and that of propranolol with the alpha 1-acid glycoprotein (alpha 1-AGP) concentration. Phenytoin albumin Homo sapiens
2 In stepwise multiple regression analysis, the most significant variable for phenytoin free fraction was serum albumin concentration, with the serum urea concentration coming in second place. Phenytoin albumin Homo sapiens
3 When the effect of serum albumin level was corrected mathematically, the urea level was the best determinant in regression analysis for both the phenytoin and diazepam free fractions. Phenytoin albumin Homo sapiens