Title : Cholecystokinin facilitates ejaculation in male rats: blockade with proglumide and apomorphine.

Pub. Date : 1987 Sep 23

PMID : 3666030






3 Functional Relationships(s)
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1 Systemic administration of the active, sulfated form of cholecystokinin-octapeptide (CCK-8S), at a dose known to inhibit dopamine (DA) release, significantly reduced the latency to ejaculate and number of intromissions preceding ejaculation in sexually active male rats. Dopamine cholecystokinin Rattus norvegicus
2 Systemic administration of the active, sulfated form of cholecystokinin-octapeptide (CCK-8S), at a dose known to inhibit dopamine (DA) release, significantly reduced the latency to ejaculate and number of intromissions preceding ejaculation in sexually active male rats. Dopamine cholecystokinin Rattus norvegicus
3 These data suggest that CCK-8S and apomorphine may reduce the ejaculation threshold in sexually active male rats by inhibition of DA release via two different mechanisms of action. Dopamine cholecystokinin Rattus norvegicus