Title : Effects of cholesterol analogues and inhibitors on the heme moiety of cytochrome P-450scc: a resonance Raman study.

Pub. Date : 1987 Jul 14

PMID : 3663604






1 Functional Relationships(s)
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1 These findings suggest the existence of the following physiologically important natures of the cytochrome P-450scc active site: (1) there is a strong steric interaction between heme-bound carbon monoxide and the 22(R)-hydroxyl group or the 22(R)-hydrogen of the steroid side chain and (2) the hydroxylation at the 20S position may cause a conformational change of the side-chain group relative to the heme. Steroids cytochrome P450 family 11 subfamily A member 1 Homo sapiens