Title : Heat and sodium arsenite act synergistically on the induction of heat shock gene expression in Xenopus laevis A6 cells.

Pub. Date : 1987 Apr

PMID : 3606855






8 Functional Relationships(s)
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1 Heat shock protein (HSP) synthesis was studied in the Xenopus epithelial cell line A6 in response to heat and sodium arsenite, either singly or together. sodium arsenite heat shock 70kDa protein L homeolog Xenopus laevis
2 Heat shock protein (HSP) synthesis was studied in the Xenopus epithelial cell line A6 in response to heat and sodium arsenite, either singly or together. sodium arsenite heat shock 70kDa protein L homeolog Xenopus laevis
3 In cultures exposed to 10 microM sodium arsenite at 30 degrees C, HSP synthesis in the 68- to 73-kDa and 29- to 31-kDa regions was much greater than the HSP synthesis in response to each treatment individually. sodium arsenite heat shock 70kDa protein L homeolog Xenopus laevis
4 In cultures exposed to 10 microM sodium arsenite at 30 degrees C, HSP synthesis in the 68- to 73-kDa and 29- to 31-kDa regions was much greater than the HSP synthesis in response to each treatment individually. sodium arsenite heat shock 70kDa protein L homeolog Xenopus laevis
5 Sodium arsenite (10-100 microM) also induced the accumulation of both HSP 70 and 30 mRNAs. sodium arsenite heat shock 70kDa protein L homeolog Xenopus laevis
6 Finally, a mild heat shock (30 degrees C) plus a low concentration of sodium arsenite (10 microM) acted synergistically on HSP 70 and 30 mRNA accumulation in A6 cells. sodium arsenite heat shock 70kDa protein L homeolog Xenopus laevis
7 Thus sodium arsenite and heat act synergistically at the level of both HSP synthesis and HSP mRNA accumulation. sodium arsenite heat shock 70kDa protein L homeolog Xenopus laevis
8 Thus sodium arsenite and heat act synergistically at the level of both HSP synthesis and HSP mRNA accumulation. sodium arsenite heat shock 70kDa protein L homeolog Xenopus laevis