Pub. Date : 1987 Jun
PMID : 3598910
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Decreased elimination of unbound prazosin in the presence of alpha 1-acid glycoprotein in the rat in vivo. | Prazosin | orosomucoid 1 | Rattus norvegicus |
| 2 | Administration of 40 and 100 mg/kg of AAG decreased the unbound fraction in plasma of prazosin from 0.238 to 0.175 and 0.090, respectively. | Prazosin | orosomucoid 1 | Rattus norvegicus |
| 3 | Administration of 40 mg/kg of AAG decreased the clearance of prazosin with respect to unbound drug (CLu) on the average by 40%. | Prazosin | orosomucoid 1 | Rattus norvegicus |
| 4 | Because prazosin is a low-to-medium extraction ratio compound in the rat, this decrease in CLu indicates that AAG has an inhibitory effect on the elimination of prazosin that goes beyond a simple protein binding effect. | Prazosin | orosomucoid 1 | Rattus norvegicus |
| 5 | Because prazosin is a low-to-medium extraction ratio compound in the rat, this decrease in CLu indicates that AAG has an inhibitory effect on the elimination of prazosin that goes beyond a simple protein binding effect. | Prazosin | orosomucoid 1 | Rattus norvegicus |