Title : Triazolodiazepines are potent antagonists of platelet activating factor (PAF) in vitro and in vivo.

Pub. Date : 1987 Mar

PMID : 3587377






1 Functional Relationships(s)
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1 The triazolodiazepines brotizolam, triazolam and alprazolam inhibited PAF-induced human platelet aggregation in vitro (IC50 = 0.54, 7.6 and 13.7 microM, respectively) but showed only a weak or no effect against other aggregating agents (ADP, adrenaline, collagen, serotonin, arachidonic acid). Epinephrine PCNA clamp associated factor Homo sapiens