Pub. Date : 1987 Jun 5
PMID : 3584128
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | The strong interaction between heparin and HRG was demonstrated to be competitive with the binding of both antithrombin and thrombin to the heparin chain. | Heparin | prothrombin | Oryctolagus cuniculus |
2 | The strong interaction between heparin and HRG was demonstrated to be competitive with the binding of both antithrombin and thrombin to the heparin chain. | Heparin | prothrombin | Oryctolagus cuniculus |
3 | HRG was further tested as a modulator of the anticoagulant activity of heparin by comparing rates of the heparin-catalyzed reaction between antithrombin and thrombin in the presence and absence of added HRG. | Heparin | prothrombin | Oryctolagus cuniculus |
4 | HRG was further tested as a modulator of the anticoagulant activity of heparin by comparing rates of the heparin-catalyzed reaction between antithrombin and thrombin in the presence and absence of added HRG. | Heparin | prothrombin | Oryctolagus cuniculus |
5 | The heparin-antithrombin-thrombin reaction was modeled using the formalism of a two-substrate enzyme-catalyzed reaction with heparin as the enzyme and HRG analyzed as an enzyme inhibitor. | Heparin | prothrombin | Oryctolagus cuniculus |
6 | Since little change in the rate of the heparin-catalyzed inhibition of thrombin by antithrombin occurs in this pH region, the dramatic change in HRG inhibition seen upon pH titration may reflect increasing ionic interaction between heparin and HRG due to the protonation of histidine residues which occurs in this pH region. | Heparin | prothrombin | Oryctolagus cuniculus |