Title : Influence of psoralen on NAT activity and melatonin levels in rat pineal gland during the daily period of darkness.

Pub. Date : 1987

PMID : 3582276






4 Functional Relationships(s)
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1 By 4 h into the dark period (at 2400 h), the NAT activity in both 8-MOP injected groups of rats was greater than that in vehicle treated animals; again, however, 8-MOP treatment did not influence the pineal melatonin content. Methoxsalen N-acetyltransferase 1 Rattus norvegicus
2 At 0200 h (6 h into the dark period), the difference between the NAT activity in pineals of rats treated with 5 mg/kg 8-MOP and the vehicle was not statistically significant, but the animals that received 10 mg/kg drug still had statistically elevated levels of the serotonin acetylating enzyme. Methoxsalen N-acetyltransferase 1 Rattus norvegicus
3 Rats given 5mg/kg 8-MOP always had NAT values intermediate between those of rats injected with vehicle and those that received 10 mg/kg 8-MOP suggesting that the NAT response to the drug was dose related. Methoxsalen N-acetyltransferase 1 Rattus norvegicus
4 Rats given 5mg/kg 8-MOP always had NAT values intermediate between those of rats injected with vehicle and those that received 10 mg/kg 8-MOP suggesting that the NAT response to the drug was dose related. Methoxsalen N-acetyltransferase 1 Rattus norvegicus