Title : Oncomodulin. 1H NMR and optical stopped-flow spectroscopic studies of its solution conformation and metal-binding properties.

Pub. Date : 1987 May 5

PMID : 3571255






2 Functional Relationships(s)
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1 Like the CD site in oncomodulin, site III in troponin C has not only a lower affinity for calcium relative to the CD site of parvalbumins but also aspartic acid at its -X position; a water molecule bridges the gap between bound metal and the carboxyl group of the relatively short side chain of Asp-114 (Herzberg, O. Water oncomodulin Homo sapiens
2 Hence, we suggest that Asp-59 in oncomodulin binds metal only indirectly through an intervening water molecule, a proposal which is consistent with the CD site"s reduced affinity for ions the size of Ca(II) or smaller. Water oncomodulin Homo sapiens