Title : Molecular Cross-Talk between Integrins and Cadherins Leads to a Loss of Vascular Barrier Integrity during SARS-CoV-2 Infection.

Pub. Date : 2022 Apr 25

PMID : 35632633






1 Functional Relationships(s)
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1 Both extracellular and intracellular inhibitors of integrin alphaVbeta3 prevented these effects, similarly to the RGD-cyclic peptide compound Cilengitide, which suggests that the spike protein-through its RGD motif-binds to alphaVbeta3 and elicits vascular leakage events. Peptides, Cyclic surface glycoprotein Severe acute respiratory syndrome coronavirus 2