Title : Identification of a Novel Inhibitor of TfR1 from Designed and Synthesized Muriceidine A Derivatives.

Pub. Date : 2022 Apr 25

PMID : 35624697






6 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The transferrin receptor 1 (TfR1) plays a key role in cellular iron uptake through its interaction with iron-bound Tf. Iron transferrin receptor Homo sapiens
2 The transferrin receptor 1 (TfR1) plays a key role in cellular iron uptake through its interaction with iron-bound Tf. Iron transferrin receptor Homo sapiens
3 The transferrin receptor 1 (TfR1) plays a key role in cellular iron uptake through its interaction with iron-bound Tf. Iron transferrin receptor Homo sapiens
4 The transferrin receptor 1 (TfR1) plays a key role in cellular iron uptake through its interaction with iron-bound Tf. Iron transferrin receptor Homo sapiens
5 Further pharmacological research showed that 12b bound to Transferrin receptor 1 (TfR1) directly caused iron deprivation and ROS imbalance along with the degradations of several oncoproteins, especially FGFR1, through the proteasome pathway; thus, inducing cell cycle arrest and apoptosis in MDA-MB-231 breast cancer cells. Iron transferrin receptor Homo sapiens
6 Further pharmacological research showed that 12b bound to Transferrin receptor 1 (TfR1) directly caused iron deprivation and ROS imbalance along with the degradations of several oncoproteins, especially FGFR1, through the proteasome pathway; thus, inducing cell cycle arrest and apoptosis in MDA-MB-231 breast cancer cells. Iron transferrin receptor Homo sapiens