Title : Regulation of proton partitioning in kinase-activating acute myeloid leukemia and its therapeutic implication.

Pub. Date : 2022 May 27

PMID : 35624145






2 Functional Relationships(s)
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1 Thirteen kinases were found to activate sodium/hydrogen exchanger (NHE1) in normal hematopoietic progenitors, of which FLT3-ITD, KRASG12D, and BTK phosphorylated NHE1 maintained alkaline intracellular pH (pHi) and supported survival of AML cells. Sodium solute carrier family 9 member A1 Homo sapiens
2 Thirteen kinases were found to activate sodium/hydrogen exchanger (NHE1) in normal hematopoietic progenitors, of which FLT3-ITD, KRASG12D, and BTK phosphorylated NHE1 maintained alkaline intracellular pH (pHi) and supported survival of AML cells. Sodium solute carrier family 9 member A1 Homo sapiens