Title : Obeticholic Acid Induces Hepatoxicity Via FXR in the NAFLD Mice.

Pub. Date : 2022

PMID : 35614939






2 Functional Relationships(s)
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1 Furthermore, high-dose OCA induced cholesterol accumulation in livers via the upregulation of genes involved in cholesterol acquisition and downregulation of genes regulating cholesterol degradation in liver, leading to the production of interleukin -1beta and an FXR-mediated inflammatory response. Cholesterol interleukin 1 beta Mus musculus
2 Furthermore, high-dose OCA induced cholesterol accumulation in livers via the upregulation of genes involved in cholesterol acquisition and downregulation of genes regulating cholesterol degradation in liver, leading to the production of interleukin -1beta and an FXR-mediated inflammatory response. Cholesterol interleukin 1 beta Mus musculus