Title : Spatiotemporal feedforward between PKM2 tetramers and mTORC1 prompts mTORC1 activation.

Pub. Date : 2022 Jun 13

PMID : 35613602






1 Functional Relationships(s)
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1 The lysosomal localization of PKM2 tetramers enables rapid increases in local ATP concentrations around lysosomes to activate mTORC1, while bypassing the need to elevate global ATP levels in the entire cell. Adenosine Triphosphate CREB regulated transcription coactivator 1 Mus musculus