Title : A mechanism for exocyst-mediated tethering via Arf6 and PIP5K1C-driven phosphoinositide conversion.

Pub. Date : 2022 May 14

PMID : 35609603






1 Functional Relationships(s)
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1 Through reconstitution and epithelial cell biology experiments, we show that Arf6-mediated recruitment of the lipid kinase PIP5K1C rapidly converts phosphatidylinositol 4-phosphate (PI(4)P) to PI(4,5)P2, driving exocyst recruitment and membrane tethering. pi(4,5)p2 ADP ribosylation factor 6 Homo sapiens