Pub. Date : 2022 May 20
PMID : 35605662
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Selective PPARdelta agonist seladelpar suppresses bile acid synthesis by reducing hepatocyte CYP7A1 via the fibroblast growth factor 21 signaling pathway. | Seladelpar | cytochrome P450, family 7, subfamily a, polypeptide 1 | Mus musculus |
| 2 | We show that administration of seladelpar to wild type mice repressed the liver expression of cholesterol 7 alpha-hydroxylase (Cyp7a1), the rate-limiting enzyme for bile acid synthesis, and decreased plasma 7alpha-hydroxy-4-cholesten-3-one (C4), a freely diffusible metabolite downstream of Cyp7a1. | Seladelpar | cytochrome P450, family 7, subfamily a, polypeptide 1 | Mus musculus |
| 3 | We show that administration of seladelpar to wild type mice repressed the liver expression of cholesterol 7 alpha-hydroxylase (Cyp7a1), the rate-limiting enzyme for bile acid synthesis, and decreased plasma 7alpha-hydroxy-4-cholesten-3-one (C4), a freely diffusible metabolite downstream of Cyp7a1. | Seladelpar | cytochrome P450, family 7, subfamily a, polypeptide 1 | Mus musculus |
| 4 | We show that administration of seladelpar to wild type mice repressed the liver expression of cholesterol 7 alpha-hydroxylase (Cyp7a1), the rate-limiting enzyme for bile acid synthesis, and decreased plasma 7alpha-hydroxy-4-cholesten-3-one (C4), a freely diffusible metabolite downstream of Cyp7a1. | Seladelpar | cytochrome P450, family 7, subfamily a, polypeptide 1 | Mus musculus |
| 5 | In primary mouse hepatocytes, we found seladelpar significantly reduced the expression of Cyp7a1 independent of the nuclear bile acid receptor, Farnesoid X receptor (FXR). | Seladelpar | cytochrome P450, family 7, subfamily a, polypeptide 1 | Mus musculus |
| 6 | The suppressive effect of seladelpar on Cyp7a1 expression was blocked by a JNK inhibitor as well as in the absence of Fgf21, indicating that Fgf21 plays an indispensable role in PPARdelta-mediated downregulation of Cyp7a1. | Seladelpar | cytochrome P450, family 7, subfamily a, polypeptide 1 | Mus musculus |
| 7 | The suppressive effect of seladelpar on Cyp7a1 expression was blocked by a JNK inhibitor as well as in the absence of Fgf21, indicating that Fgf21 plays an indispensable role in PPARdelta-mediated downregulation of Cyp7a1. | Seladelpar | cytochrome P450, family 7, subfamily a, polypeptide 1 | Mus musculus |