Title : Association of p53 with Neurodegeneration in Parkinson's Disease.

Pub. Date : 2022

PMID : 35601652






2 Functional Relationships(s)
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1 p53 activation in response to neurodegenerative stress is closely associated with the degeneration of dopaminergic neurons accompanied by mitochondrial dysfunction, reactive oxygen species (ROS) production, abnormal protein aggregation, and impairment of autophagy, and these pathogenic events have been implicated in the pathogenesis of PD. Reactive Oxygen Species tumor protein p53 Homo sapiens
2 p53 activation in response to neurodegenerative stress is closely associated with the degeneration of dopaminergic neurons accompanied by mitochondrial dysfunction, reactive oxygen species (ROS) production, abnormal protein aggregation, and impairment of autophagy, and these pathogenic events have been implicated in the pathogenesis of PD. Reactive Oxygen Species tumor protein p53 Homo sapiens