Title : Novel Starting Points for Human Glycolate Oxidase Inhibitors, Revealed by Crystallography-Based Fragment Screening.

Pub. Date : 2022

PMID : 35601556






1 Functional Relationships(s)
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1 Oxidation of glycolate by glycolate oxidase (or hydroxy acid oxidase 1, HAO1) is a major cellular source of glyoxylate, and siRNA studies have shown phenotypic rescue of PH1 by the knockdown of HAO1, representing a promising inhibitor target. glyoxylic acid hydroxyacid oxidase 2 Homo sapiens