Title : New mixed ligand oxidovanadium(IV) complexes: Solution behavior, protein interaction and cytotoxicity.

Pub. Date : 2022 Aug

PMID : 35598422






1 Functional Relationships(s)
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1 The studies on the interaction with two proteins, lysozyme (Lyz) chosen as a representative model of a small protein, and human serum albumin (HSA) show that two types of binding are possible: a non-covalent binding through the accessible residues on protein surface with (VIVO(L1-3)(LNN)) keeping its octahedral structure, and a covalent binding upon the replacement of water in (VIVO(L1-3)(H2O)) with His-N donors to form VIVO(L1-3)(HSA). Histidine albumin Homo sapiens