Title : Bisphenol A exposure induces metastatic aggression in low metastatic MCF-7 cells via PGC-1α mediated mitochondrial biogenesis and epithelial-mesenchymal plasticity.

Pub. Date : 2022 May 18

PMID : 35597549






3 Functional Relationships(s)
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1 MAIN METHODS: Low metastatic ERalpha-positive human breast cancer cells (MCF-7) were exposed to nanomolar doses of BPA every 24 h (up to 200 days) to study the effect of repeated exposure on metastatic potential. bisphenol A estrogen receptor 1 Homo sapiens
2 KEY FINDINGS: A repeated exposure of low dose BPA induced stable epithelial-mesenchymal plasticity in MCF-7 cells to augment migration and invasion in the ERalpha-dependent pathway. bisphenol A estrogen receptor 1 Homo sapiens
3 SIGNIFICANCE: Repeated exposures of low dose BPA may induce metastatic aggression in ERalpha-positive breast cancer cells via PGC-1alpha-mediated mitochondrial biogenesis and epithelial-mesenchymal plasticity. bisphenol A estrogen receptor 1 Homo sapiens