Title : An integrated biomarker of PD-L1 expression and intraepithelial CD8+ T cell infiltration was associated with the prognosis of lung cancer patients after intracranial resection of brain metastases.

Pub. Date : 2022 May 20

PMID : 35596539






3 Functional Relationships(s)
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1 There was a disagreement in PD-L1 expression on TCs between paired BM and PL lesions in 15 cases and on ICs in seven cases. 9-ethyl-N-(3,4,5-trimethoxyphenyl)carbazole-3-sulfonamide CD274 molecule Homo sapiens
2 PD-L1 positivity on both TCs and ICs was associated with a better post-BM-surgery prognosis (p = 0.010; p = 0.041). 9-ethyl-N-(3,4,5-trimethoxyphenyl)carbazole-3-sulfonamide CD274 molecule Homo sapiens
3 Notably, PD-L1 positivity on TCs and a high level of intraepithelial CD8+ T cell infiltration could serve as an integrated biomarker that indicates longer survival time (p = 0.004) in LC patients. 9-ethyl-N-(3,4,5-trimethoxyphenyl)carbazole-3-sulfonamide CD274 molecule Homo sapiens