Title : Isoleucine stimulates mTOR and SREBP-1c gene expression for milk synthesis in mammary epithelial cells through BRG1-mediated chromatin remodelling.

Pub. Date : 2022 May 20

PMID : 35593529






2 Functional Relationships(s)
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1 Ile dose-dependently affected milk protein and fat synthesis, mTOR phosphorylation, SREBP-1c expression and maturation, and BRG1 protein expression in bovine MECs. Isoleucine mechanistic target of rapamycin kinase Bos taurus
2 ChIP-PCR analysis detected that BRG1 bound to the promoters of mTOR and SREBP-1c, and ChIP-qPCR further detected that these binding were increased by Ile stimulation. Isoleucine mechanistic target of rapamycin kinase Bos taurus