Title : Structure-based discovery and development of novel O-GlcNAcase inhibitors for the treatment of Alzheimer's disease.

Pub. Date : 2022 Aug 5

PMID : 35588599






2 Functional Relationships(s)
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Protein Name
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1 In acute AD model mice, 39 was more effective than Thiamet-G in inhibiting OGA activity attributable to its better blood-brain barrier permeability. thiamet O-GlcNAcase Mus musculus
2 In addition, 39 restored the cognitive function in mice and reduced amyloid-beta (Abeta) concentrations to a greater extent than Thiamet-G. Molecular docking studies demonstrated that 39 was well associated with OGA through H-bonds and hydrophobic interaction. thiamet O-GlcNAcase Mus musculus