Pub. Date : 2022 Jul
PMID : 35582997
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The present study aimed to evaluate the regulatory effect of the Notch1/hairy and enhancer of split 1 (Hes1)-PTEN/AKT/IL-17A feedback loop on Th17 cell differentiation via the PI3K/AKT inhibitor LY294002 in a mouse model of psoriasis. | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one | thymoma viral proto-oncogene 1 | Mus musculus |
| 2 | The present study aimed to evaluate the regulatory effect of the Notch1/hairy and enhancer of split 1 (Hes1)-PTEN/AKT/IL-17A feedback loop on Th17 cell differentiation via the PI3K/AKT inhibitor LY294002 in a mouse model of psoriasis. | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one | thymoma viral proto-oncogene 1 | Mus musculus |
| 3 | Additionally, splenic mononuclear cells from model mice were treated by 10 and 50 microM LY294002 to further evaluate its regulatory effect on Notch1/Hes1-PTEN/AKT/IL-17A feedback loop. | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one | thymoma viral proto-oncogene 1 | Mus musculus |
| 4 | In addition, LY294002 treatment reversed the increased Th17 cell percentage, as well as the increased expression of Notch1, NICD1, Hes1, AKT, p-AKT, mTORC1, p-mTORC1, S6K1, S6K2 and IL-17A, and the decreased expression of PTEN. | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one | thymoma viral proto-oncogene 1 | Mus musculus |
| 5 | In addition, LY294002 treatment reversed the increased Th17 cell percentage, as well as the increased expression of Notch1, NICD1, Hes1, AKT, p-AKT, mTORC1, p-mTORC1, S6K1, S6K2 and IL-17A, and the decreased expression of PTEN. | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one | thymoma viral proto-oncogene 1 | Mus musculus |
| 6 | In vitro study from 5% IMQ-induced mouse splenic mononuclear cells presented that high dose of LY294002 exerted more obviously regulatory effect on Notch1/Hes1-PTEN/AKT/IL-17A feedback loop. | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one | thymoma viral proto-oncogene 1 | Mus musculus |