Title : T-lymphocyte tyrosine hydroxylase regulates TH17 T-lymphocytes during repeated social defeat stress.

Pub. Date : 2022 May 14

PMID : 35580792






2 Functional Relationships(s)
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1 RSDS characteristically increased tumor necrosis factor-alpha (TNFalpha), IL-6, IL-17A, and IL-22, however, IL-17A and IL-22 (TH17 produced cytokines) were selectively attenuated in circulation and in T-lymphocytes of THT-KO animals. tetrahydrothiophene interleukin 22 Homo sapiens
2 When activated ex vivo, secretion of IL-17A and IL-22 by THT-KO T-lymphocytes was also found to be reduced, but could be partially rescued with supplementation of norepinephrine specifically. tetrahydrothiophene interleukin 22 Homo sapiens