Title : Clustering extent-dependent differential signaling by CLEC-2 receptors in platelets.

Pub. Date : 2022 Mar

PMID : 35573643






1 Functional Relationships(s)
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1 Results and Conclusions: Platelet activation and downstream signaling were abolished in murine and human platelets in the presence of the Btk inhibitors ibrutinib or acalabrutinib when a low concentration of a CLEC-2 antibody was used to crosslink CLEC-2 receptors. ibrutinib Bruton tyrosine kinase Homo sapiens