Title : Larixol inhibits fMLP-induced superoxide anion production and chemotaxis by targeting the βγ subunit of Gi-protein of fMLP receptor in human neutrophils.

Pub. Date : 2022 Jul

PMID : 35569521






3 Functional Relationships(s)
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1 Larixol inhibits fMLP-induced superoxide anion production and chemotaxis by targeting the betagamma subunit of Gi-protein of fMLP receptor in human neutrophils. Superoxides formyl peptide receptor 1 Homo sapiens
2 Briefly, larixol inhibited fMLP (0.1 muM)-induced superoxide anion production (IC50:1.98 +- 0.14 muM), the release of cathepsin G (IC50:2.76 +- 0.15 muM) and chemotaxis in a concentration-dependent manner; however, larixol did not inhibit these functions induced by PMA (100 nM). Superoxides formyl peptide receptor 1 Homo sapiens
3 These results suggest that larixol modulated fMLP-induced neutrophils superoxide anion production, chemotaxis, and granular releases by interrupting the interaction of the betagamma subunits of Gi-protein with downstream signaling of the fMLP receptor. Superoxides formyl peptide receptor 1 Homo sapiens