Title : RNase 7 Inhibits Uropathogenic Escherichia coli-Induced Inflammation in Bladder Cells under a High-Glucose Environment by Regulating the JAK/STAT Signaling Pathway.

Pub. Date : 2022 May 5

PMID : 35563546






2 Functional Relationships(s)
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1 RNase 7-induced decrease in UPEC infection in a high-glucose environment not only downregulated the expression of TLR4 protein and the JAK/STAT signaling pathway but also decreased UPEC-induced secretion of exogenous inflammatory IL-6 and IL-8 cytokines, although IL-8 levels increased in the 25 mug/mL RNase 7-treated group. Glucose ribonuclease A family member 7 Homo sapiens
2 The present study showed the suppressive effects of RNase 7 on UPEC infection and induced inflammation in bladder epithelial cells in a high-glucose environment. Glucose ribonuclease A family member 7 Homo sapiens