Pub. Date : 2022 May 12
PMID : 35552354
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ferutinin induces osteoblast differentiation of DPSCs via induction of KLF2 and autophagy/mitophagy. | 4-oxy-6-(4-oxybezoyloxy)dauc-8,9-en | Kruppel like factor 2 | Homo sapiens |
| 2 | We demonstrate the significantly increased expression level of a transcription factor, Kruppel-like factor 2 (KLF2) along with autophagy-related molecules in DPSCs after induction with ferutinin. | 4-oxy-6-(4-oxybezoyloxy)dauc-8,9-en | Kruppel like factor 2 | Homo sapiens |
| 3 | We demonstrate the significantly increased expression level of a transcription factor, Kruppel-like factor 2 (KLF2) along with autophagy-related molecules in DPSCs after induction with ferutinin. | 4-oxy-6-(4-oxybezoyloxy)dauc-8,9-en | Kruppel like factor 2 | Homo sapiens |
| 4 | The loss-of-function and the gain-of-function approaches of KLF2 confirmed that the ferutinin-induced KLF2 modulated autophagic and OB differentiation-related molecules. | 4-oxy-6-(4-oxybezoyloxy)dauc-8,9-en | Kruppel like factor 2 | Homo sapiens |
| 5 | The loss-of-function and the gain-of-function approaches of KLF2 confirmed that the ferutinin-induced KLF2 modulated autophagic and OB differentiation-related molecules. | 4-oxy-6-(4-oxybezoyloxy)dauc-8,9-en | Kruppel like factor 2 | Homo sapiens |
| 6 | Furthermore, mechanistically, chromatin immunoprecipitation (ChIP) analysis revealed that the addition of ferutinin in DPSCs not only induced the level of KLF2, but also induced the transcriptionally active epigenetic marks (H3K27Ac and H3K4me3) on the promoter region of the autophagic molecule ATG7. | 4-oxy-6-(4-oxybezoyloxy)dauc-8,9-en | Kruppel like factor 2 | Homo sapiens |
| 7 | These results provide strong evidence that ferutinin stimulates OB differentiation via induction of KLF2-mediated autophagy/mitophagy. | 4-oxy-6-(4-oxybezoyloxy)dauc-8,9-en | Kruppel like factor 2 | Homo sapiens |