Pub. Date : 2022 Jun
PMID : 35550167
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Epigenetic regulation of the DNMT1/MT1G/KLF4/CA9 axis synergizes the anticancer effects of sorafenib in hepatocellular carcinoma. | Sorafenib | metallothionein 1G | Homo sapiens |
| 2 | Herein, we report that sorafenib exerts its anticancer effects by activating metallothionein 1G (MT1G) expression. | Sorafenib | metallothionein 1G | Homo sapiens |
| 3 | Herein, we report that sorafenib exerts its anticancer effects by activating metallothionein 1G (MT1G) expression. | Sorafenib | metallothionein 1G | Homo sapiens |
| 4 | MT1G overexpression suppressed the cellular proliferation, migration, invasion, and tumour formation of HCC and sensitized cells to sorafenib treatment. | Sorafenib | metallothionein 1G | Homo sapiens |
| 5 | However, the disruption of MT1G attenuated the anticancer effects of sorafenib. | Sorafenib | metallothionein 1G | Homo sapiens |
| 6 | Mechanistically, sorafenib upregulated MT1G expression via hypomethylation of its promoter region by binding and inhibiting DNA methyltransferase 1 (DNMT1) and increasing its promoter accessibility in HCC cells. | Sorafenib | metallothionein 1G | Homo sapiens |
| 7 | Our collective data revealed that sorafenib exerts its anticancer effects through epigenetic regulation of the DNMT1/MT1G/KLF4/CA9 axis in HCC and the activation of MT1G might constitute a strategy for enhancing the effect of sorafenib to suppress HCC cells. | Sorafenib | metallothionein 1G | Homo sapiens |
| 8 | Our collective data revealed that sorafenib exerts its anticancer effects through epigenetic regulation of the DNMT1/MT1G/KLF4/CA9 axis in HCC and the activation of MT1G might constitute a strategy for enhancing the effect of sorafenib to suppress HCC cells. | Sorafenib | metallothionein 1G | Homo sapiens |