Pub. Date : 2022 Feb 28
PMID : 35545407
30 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Knockout of farnesoid X receptor gene aggravates cisplatin-induced kidney injury. | Cisplatin | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |
| 2 | This study aims to investigate the role of FXR in cisplatin-induced acute renal injury and whether its mechanism is related to autophagy regulation. | Cisplatin | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |
| 3 | The WT+cisplatin group and the FXR-KO+cisplatin group were intraperitoneally injected with cisplatin (20 mg/kg), and the WT group and the FXR-KO group were intraperitoneally injected with equal volume of cisplatin solvent. | Cisplatin | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |
| 4 | RESULTS: Compared with the WT group or the FXR-KO group, both SCr and BUN levels in the WT+cisplatin group or the FXR-KO+cisplatin group were significantly increased (P<0.01 or P<0.001), and SCr and BUN levels in the FXR-KO+cisplatin group were significantly higher than those in the WT+cisplatin group (both P<0.05). | Cisplatin | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |
| 5 | RESULTS: Compared with the WT group or the FXR-KO group, both SCr and BUN levels in the WT+cisplatin group or the FXR-KO+cisplatin group were significantly increased (P<0.01 or P<0.001), and SCr and BUN levels in the FXR-KO+cisplatin group were significantly higher than those in the WT+cisplatin group (both P<0.05). | Cisplatin | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |
| 6 | RESULTS: Compared with the WT group or the FXR-KO group, both SCr and BUN levels in the WT+cisplatin group or the FXR-KO+cisplatin group were significantly increased (P<0.01 or P<0.001), and SCr and BUN levels in the FXR-KO+cisplatin group were significantly higher than those in the WT+cisplatin group (both P<0.05). | Cisplatin | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |
| 7 | RESULTS: Compared with the WT group or the FXR-KO group, both SCr and BUN levels in the WT+cisplatin group or the FXR-KO+cisplatin group were significantly increased (P<0.01 or P<0.001), and SCr and BUN levels in the FXR-KO+cisplatin group were significantly higher than those in the WT+cisplatin group (both P<0.05). | Cisplatin | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |
| 8 | RESULTS: Compared with the WT group or the FXR-KO group, both SCr and BUN levels in the WT+cisplatin group or the FXR-KO+cisplatin group were significantly increased (P<0.01 or P<0.001), and SCr and BUN levels in the FXR-KO+cisplatin group were significantly higher than those in the WT+cisplatin group (both P<0.05). | Cisplatin | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |
| 9 | RESULTS: Compared with the WT group or the FXR-KO group, both SCr and BUN levels in the WT+cisplatin group or the FXR-KO+cisplatin group were significantly increased (P<0.01 or P<0.001), and SCr and BUN levels in the FXR-KO+cisplatin group were significantly higher than those in the WT+cisplatin group (both P<0.05). | Cisplatin | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |
| 10 | Both the WT+cisplatin group and the FXR-KO+cisplatin group had vacuolar or granular degeneration of renal tubular epithelial cells, flat cells, lumen expansion, brush edge falling off, and even exposed basement membrane and tubular formation. | Cisplatin | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |
| 11 | The scores of renal tubular injury in the WT+cisplatin group and the FXR-KO+cisplatin group were significantly higher than those in the WT group and the FXR-KO group, respectively (both P<0.001), and the score in the FXR-KO+cisplatin group was significantly higher than that in the WT+cisplatin group (P<0.05). | Cisplatin | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |
| 12 | The scores of renal tubular injury in the WT+cisplatin group and the FXR-KO+cisplatin group were significantly higher than those in the WT group and the FXR-KO group, respectively (both P<0.001), and the score in the FXR-KO+cisplatin group was significantly higher than that in the WT+cisplatin group (P<0.05). | Cisplatin | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |
| 13 | The scores of renal tubular injury in the WT+cisplatin group and the FXR-KO+cisplatin group were significantly higher than those in the WT group and the FXR-KO group, respectively (both P<0.001), and the score in the FXR-KO+cisplatin group was significantly higher than that in the WT+cisplatin group (P<0.05). | Cisplatin | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |
| 14 | The scores of renal tubular injury in the WT+cisplatin group and the FXR-KO+cisplatin group were significantly higher than those in the WT group and the FXR-KO group, respectively (both P<0.001), and the score in the FXR-KO+cisplatin group was significantly higher than that in the WT+cisplatin group (P<0.05). | Cisplatin | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |
| 15 | The scores of renal tubular injury in the WT+cisplatin group and the FXR-KO+cisplatin group were significantly higher than those in the WT group and the FXR-KO group, respectively (both P<0.001), and the score in the FXR-KO+cisplatin group was significantly higher than that in the WT+cisplatin group (P<0.05). | Cisplatin | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |
| 16 | Under the transmission electron microscope, the mitochondria of mouse tubular epithelial cell in the WT+cisplatin group and the FXR-KO+cisplatin group was swollen, round, vacuolated, cristae broken or disappeared; the lysosome was uneven and high-density clumps, and the change was more obvious in the FXR-KO+cisplatin group. | Cisplatin | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |
| 17 | Under the transmission electron microscope, the mitochondria of mouse tubular epithelial cell in the WT+cisplatin group and the FXR-KO+cisplatin group was swollen, round, vacuolated, cristae broken or disappeared; the lysosome was uneven and high-density clumps, and the change was more obvious in the FXR-KO+cisplatin group. | Cisplatin | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |
| 18 | Under the transmission electron microscope, the mitochondria of mouse tubular epithelial cell in the WT+cisplatin group and the FXR-KO+cisplatin group was swollen, round, vacuolated, cristae broken or disappeared; the lysosome was uneven and high-density clumps, and the change was more obvious in the FXR-KO+cisplatin group. | Cisplatin | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |
| 19 | Immunohistochemistry results showed that the expression of total LC3 and p62 in renal cortex of the WT+cisplatin group and the FXR-KO+cisplatin group was increased significantly, especially in the FXR-KO+cisplatin group. | Cisplatin | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |
| 20 | Immunohistochemistry results showed that the expression of total LC3 and p62 in renal cortex of the WT+cisplatin group and the FXR-KO+cisplatin group was increased significantly, especially in the FXR-KO+cisplatin group. | Cisplatin | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |
| 21 | Immunohistochemistry results showed that the expression of total LC3 and p62 in renal cortex of the WT+cisplatin group and the FXR-KO+cisplatin group was increased significantly, especially in the FXR-KO+cisplatin group. | Cisplatin | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |
| 22 | Immunohistochemistry results showed that the expression of total LC3 and p62 in renal cortex of the WT+cisplatin group and the FXR-KO+cisplatin group was increased significantly, especially in the FXR-KO+cisplatin group. | Cisplatin | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |
| 23 | TUNEL results showed that the mice in the WT group and the FXR-KO group had negative staining or only a few apoptotic tubular epithelial cells, and the number of apoptotic cells in the WT+cisplatin group and the FXR-KO+cisplatin group were increased. | Cisplatin | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |
| 24 | TUNEL results showed that the mice in the WT group and the FXR-KO group had negative staining or only a few apoptotic tubular epithelial cells, and the number of apoptotic cells in the WT+cisplatin group and the FXR-KO+cisplatin group were increased. | Cisplatin | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |
| 25 | The apoptosis rates of renal tubular epithelial cells in the WT+cisplatin group and the FXR-KO+cisplatin group were significantly higher than those in the WT group and the FXR-KO group, respectively (both P<0.001), and the apoptosis rate in the FXR-KO+cisplatin group was significantly higher than that in the WT+cisplatin group (P<0.05). | Cisplatin | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |
| 26 | The apoptosis rates of renal tubular epithelial cells in the WT+cisplatin group and the FXR-KO+cisplatin group were significantly higher than those in the WT group and the FXR-KO group, respectively (both P<0.001), and the apoptosis rate in the FXR-KO+cisplatin group was significantly higher than that in the WT+cisplatin group (P<0.05). | Cisplatin | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |
| 27 | The apoptosis rates of renal tubular epithelial cells in the WT+cisplatin group and the FXR-KO+cisplatin group were significantly higher than those in the WT group and the FXR-KO group, respectively (both P<0.001), and the apoptosis rate in the FXR-KO+cisplatin group was significantly higher than that in the WT+cisplatin group (P<0.05). | Cisplatin | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |
| 28 | The apoptosis rates of renal tubular epithelial cells in the WT+cisplatin group and the FXR-KO+cisplatin group were significantly higher than those in the WT group and the FXR-KO group, respectively (both P<0.001), and the apoptosis rate in the FXR-KO+cisplatin group was significantly higher than that in the WT+cisplatin group (P<0.05). | Cisplatin | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |
| 29 | The apoptosis rates of renal tubular epithelial cells in the WT+cisplatin group and the FXR-KO+cisplatin group were significantly higher than those in the WT group and the FXR-KO group, respectively (both P<0.001), and the apoptosis rate in the FXR-KO+cisplatin group was significantly higher than that in the WT+cisplatin group (P<0.05). | Cisplatin | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |
| 30 | CONCLUSIONS: Knockout of FXR gene aggravates cisplatin induced acute renal injury, and its mechanism may be related to inhibiting autophagy and promoting apoptosis. | Cisplatin | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |