Title : Metformin attenuates V-domain Ig suppressor of T-cell activation through the aryl hydrocarbon receptor pathway in Melanoma: In Vivo and In Vitro Studies.

Pub. Date : 2022 Feb

PMID : 35528855






3 Functional Relationships(s)
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1 This study aims to investigate the inhibitory effect of metformin on VISTA via AHR in melanoma cells (CHL-1, B16) and animal models. Metformin V-set immunoregulatory receptor Homo sapiens
2 Here, metformin significantly decreased VISTA and AHR levels in vitro and in vivo. Metformin V-set immunoregulatory receptor Homo sapiens
3 These findings demonstrate for the first time that VISTA is suppressed by metformin and identified a new regulatory mechanism through AHR. Metformin V-set immunoregulatory receptor Homo sapiens