Pub. Date : 2022 Feb
PMID : 35528855
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | This study aims to investigate the inhibitory effect of metformin on VISTA via AHR in melanoma cells (CHL-1, B16) and animal models. | Metformin | V-set immunoregulatory receptor | Homo sapiens |
2 | Here, metformin significantly decreased VISTA and AHR levels in vitro and in vivo. | Metformin | V-set immunoregulatory receptor | Homo sapiens |
3 | These findings demonstrate for the first time that VISTA is suppressed by metformin and identified a new regulatory mechanism through AHR. | Metformin | V-set immunoregulatory receptor | Homo sapiens |