Pub. Date : 2022 Aug 5
PMID : 35526478
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Compared to non-halogenated oximes, halogenated oximes showed lower pKa of the oxime group (fluorinated < chlorinated < non-halogenated) along with higher level of oximate anion formation at the physiological pH, and had a higher binding affinity of both AChE and BChE. | Oximes | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 2 | Compared to non-halogenated oximes, halogenated oximes showed lower pKa of the oxime group (fluorinated < chlorinated < non-halogenated) along with higher level of oximate anion formation at the physiological pH, and had a higher binding affinity of both AChE and BChE. | Oximes | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 3 | Compared to non-halogenated oximes, halogenated oximes showed lower pKa of the oxime group (fluorinated < chlorinated < non-halogenated) along with higher level of oximate anion formation at the physiological pH, and had a higher binding affinity of both AChE and BChE. | Oximes | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 4 | The advantage of halogen substituents in the stabilization of oxime in a position optimal for in-line nucleophilic attack were confirmed by extensive molecular modelling of pre-reactivation complexes between the analogue oximes and phosphorylated AChE and BChE. | Oximes | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 5 | The advantage of halogen substituents in the stabilization of oxime in a position optimal for in-line nucleophilic attack were confirmed by extensive molecular modelling of pre-reactivation complexes between the analogue oximes and phosphorylated AChE and BChE. | Oximes | acetylcholinesterase (Cartwright blood group) | Homo sapiens |