Title : Co-encapsulation of l-asparaginase and etoposide in dextran nanoparticles for synergistic effect in chronic myeloid leukemia cells.

Pub. Date : 2022 Jun 25

PMID : 35525474






2 Functional Relationships(s)
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1 The enzyme l-asparaginase and the small molecule drug etoposide have a known synergistic effect against selected cancer types. Etoposide asparaginase and isoaspartyl peptidase 1 Homo sapiens
2 In this study, we present the co-encapsulation of a large hydrophilic enzyme l-asparaginase and the small hydrophobic drug etoposide into a biodegradable, biocompatible, and acid-responsive dextran-based nanoparticle system. Etoposide asparaginase and isoaspartyl peptidase 1 Homo sapiens