Pub. Date : 2022 Jun
PMID : 35514319
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Icariin inhibits the malignant progression of lung cancer by affecting the PI3K/Akt pathway through the miR-205-5p/PTEN axis. | icariin | microRNA 205 | Homo sapiens |
| 2 | In addition, miR-205-5p was upregulated in lung cancer tissues but downregulated following ICA treatment, while PTEN showed a significantly lower expression in lung cancer cells. | icariin | microRNA 205 | Homo sapiens |
| 3 | Importantly, rescue experiment results showed that ICA could target the miR-205-5p/PTEN axis to affect the PI3K/Akt signaling, thereby suppressing the malignant cell phenotype of lung cancer. | icariin | microRNA 205 | Homo sapiens |