Title : A high-throughput screening platform identifies novel combination treatments for Malignant Peripheral Nerve Sheath Tumors.

Pub. Date : 2022 May 5

PMID : 35511749






1 Functional Relationships(s)
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1 One of the combinations, MK-1775 with Doxorubicin, significantly reduced tumor growth in a sporadic PDOX model (MPNST-SP-01) (sevenfold) and in an NF1-PDOX model (MPNST-NF1-09) (fourfold) and presented greater effects in TP53 mutated MPNST cell lines. Doxorubicin tumor protein p53 Homo sapiens