Title : Pre- and post-conditioning with poly I:C exerts neuroprotective effect against cerebral ischemia injury in animal models: A systematic review and meta-analysis.

Pub. Date : 2022 May 5

PMID : 35510663






2 Functional Relationships(s)
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1 Furthermore, poly I:C upregulates TLR3 (SMD = 0.64; CIs (0.56, 0.72); p = 0.00), downregulates nuclear factor-kappaB (NF-kappaB) (SMD = -1.78; CIs (-2.67, -0.88); p = 0.0)), and tumor necrosis factor alpha (TNF-alpha) (SMD = -16.83; CIs (-22.63, -11.02); p = 0.00). Carbon toll like receptor 3 Homo sapiens
2 Further research on simultaneous activation of TLR3 with poly I:C and suppression of TLR 2/4 might open new vistas for the development of therapeutics against CI. Carbon toll like receptor 3 Homo sapiens