Pub. Date : 2022 Jun 1
PMID : 35506146
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In vitro study using HEK293 cells transfected with MC2R wild-type and mutant clones showed a defect in protein expression and cAMP generation when stimulated with ACTH. | Cyclic AMP | proopiomelanocortin | Homo sapiens |
| 2 | Conclusion: Homozygous semiconserved p.Leu109Gln mutation disrupts cAMP production and MC2R protein expression leading to ACTH resistance. | Cyclic AMP | proopiomelanocortin | Homo sapiens |