Title : New insights into the interactions of HPV-16 E6*I and E6*II with p53 isoforms and induction of apoptosis in cancer-derived cell lines.

Pub. Date : 2022 Jun

PMID : 35487028






3 Functional Relationships(s)
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1 We observed that both p53 (p = 0.0006) and Delta40p53 (p = 0.0014) induced apoptosis in cisplatin-treated SiHa cells; however in cisplatin-treated HeLa cells, only p53 induced apoptosis (p = 0.0029). Cisplatin tumor protein p53 Homo sapiens
2 We observed that both p53 (p = 0.0006) and Delta40p53 (p = 0.0014) induced apoptosis in cisplatin-treated SiHa cells; however in cisplatin-treated HeLa cells, only p53 induced apoptosis (p = 0.0029). Cisplatin tumor protein p53 Homo sapiens
3 Our findings suggest a possible therapeutic application for the combining of p53 or Delta40p53 with cisplatin to induce an increased apoptosis of cancer cells expressing E6 isoforms from HPV-16. Cisplatin tumor protein p53 Homo sapiens