Title : Apolipoprotein E potently inhibits ferroptosis by blocking ferritinophagy.

Pub. Date : 2022 Apr 28

PMID : 35484240






1 Functional Relationships(s)
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1 We demonstrate that apoE signals to activate the PI3K/AKT pathway that then inhibits the autophagic degradation of ferritin (ferritinophagy), thus averting iron-dependent lipid peroxidation. Iron AKT serine/threonine kinase 1 Homo sapiens