Pub. Date : 2022 Apr 25
PMID : 35472330
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Friedreich"s Ataxia (FRDA) is a degenerative disease caused by a decrease in the mitochondrial protein frataxin, which is involved in iron-sulfur cluster (ISC) synthesis. | Iron | frataxin | Homo sapiens |
| 2 | Friedreich"s Ataxia (FRDA) is a degenerative disease caused by a decrease in the mitochondrial protein frataxin, which is involved in iron-sulfur cluster (ISC) synthesis. | Iron | frataxin | Homo sapiens |
| 3 | Diminutions in frataxin result in decreased ISC synthesis, increased mitochondrial iron accumulation, and impaired mitochondrial function. | Iron | frataxin | Homo sapiens |
| 4 | We demonstrate that the mitochondrial Lon protease is involved in frataxin degradation and that iron export through the mitochondrial metal transporter Mmt1 protects yeast frataxin from degradation. | Iron | frataxin | Homo sapiens |
| 5 | We also determined that when FRDA fibroblasts were grown in media containing elevated iron, mitochondrial ROS increased and frataxin decreased compared to WT fibroblasts. | Iron | frataxin | Homo sapiens |
| 6 | We also determined that when FRDA fibroblasts were grown in media containing elevated iron, mitochondrial ROS increased and frataxin decreased compared to WT fibroblasts. | Iron | frataxin | Homo sapiens |