Title : Targeted autophagy disruption reveals the central role of macrophage iron metabolism in systemic iron homeostasis.

Pub. Date : 2022 Apr 26

PMID : 35472080






6 Functional Relationships(s)
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1 Iron homeostasis depends on both intracellular control through iron-responsive proteins and the systemic level of iron through hepcidin-ferroportin axis. Iron hepcidin antimicrobial peptide Mus musculus
2 Iron homeostasis depends on both intracellular control through iron-responsive proteins and the systemic level of iron through hepcidin-ferroportin axis. Iron hepcidin antimicrobial peptide Mus musculus
3 Indeed, the hormone hepcidin downregulates the ferroportin iron exporter to control iron recycling from macrophages and iron uptake from enterocytes. Iron hepcidin antimicrobial peptide Mus musculus
4 Indeed, the hormone hepcidin downregulates the ferroportin iron exporter to control iron recycling from macrophages and iron uptake from enterocytes. Iron hepcidin antimicrobial peptide Mus musculus
5 Indeed, the hormone hepcidin downregulates the ferroportin iron exporter to control iron recycling from macrophages and iron uptake from enterocytes. Iron hepcidin antimicrobial peptide Mus musculus
6 We propose that in macrophages, autophagy restricts ferroportin level and iron export resulting in hepcidin expression with an autocrine-paracrine effect that takes part in the regulation of the ferroportin expression in duodenal enterocytes. Iron hepcidin antimicrobial peptide Mus musculus