Title : MicroRNA-181a-5p prevents the progression of esophageal squamous cell carcinoma in vivo and in vitro via the MEK1-mediated ERK-MMP signaling pathway.

Pub. Date : 2022 Apr 25

PMID : 35468097






4 Functional Relationships(s)
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Protein Name
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1 Additionally, miR-181a-5p mimics lowered p-ERK1/2, MMP2 and MMP9 levels in ECA109 cells, which were restored by MEK1-OE lentivirus. mir-181a-5p mitogen-activated protein kinase kinase 1 Homo sapiens
2 MEK1-OE Lentivirus significantly reversed the function induced by miR-181a-5p mimics in ECA109 cells. mir-181a-5p mitogen-activated protein kinase kinase 1 Homo sapiens
3 In short, repressed ERK-MMP pathway mediated by miR-181a-5p can inhibit cell migration, invasion and proliferation by targeting MAP2K1 (MEK1) in ESCC. mir-181a-5p mitogen-activated protein kinase kinase 1 Homo sapiens
4 In short, repressed ERK-MMP pathway mediated by miR-181a-5p can inhibit cell migration, invasion and proliferation by targeting MAP2K1 (MEK1) in ESCC. mir-181a-5p mitogen-activated protein kinase kinase 1 Homo sapiens