Title : Characterization of Erythroferrone in a Teleost Fish (Dicentrarchus labrax) With Two Functional Hepcidin Types: More Than an Erythroid Regulator.

Pub. Date : 2022

PMID : 35464433






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Iron metabolism is affected by erythroferrone through its capacity to inhibit hepcidin production, leading to the increase of iron availability required for erythropoiesis. Iron hepcidin antimicrobial peptide Homo sapiens
2 Iron metabolism is affected by erythroferrone through its capacity to inhibit hepcidin production, leading to the increase of iron availability required for erythropoiesis. Iron hepcidin antimicrobial peptide Homo sapiens
3 However, little is known about erythroferrone function in other vertebrates, in particular teleost fish, that unlike mammals, present two different functional types of hepcidin, one type mostly involved in iron metabolism and the other in antimicrobial response. Iron hepcidin antimicrobial peptide Homo sapiens
4 In conclusion, in dual hepcidin teleost fish erythroferrone seems to only interact with type 1 hepcidin, known to be involved in iron homeostasis, but not with type 2, which has an almost exclusive antimicrobial role. Iron hepcidin antimicrobial peptide Homo sapiens