Pub. Date : 2022 Apr 18
PMID : 35448550
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, we show that TCDD exposure in mice profoundly stimulates the hepatic expression of flavin-containing monooxygenase 3 (Fmo3), which is a hepatic xenobiotic metabolizing enzyme that is also responsible for the production of the gut microbiome-associated metabolite trimethylamine N-oxide (TMAO). | Polychlorinated Dibenzodioxins | flavin containing monooxygenase 3 | Mus musculus |
| 2 | Here, we show that TCDD exposure in mice profoundly stimulates the hepatic expression of flavin-containing monooxygenase 3 (Fmo3), which is a hepatic xenobiotic metabolizing enzyme that is also responsible for the production of the gut microbiome-associated metabolite trimethylamine N-oxide (TMAO). | Polychlorinated Dibenzodioxins | flavin containing monooxygenase 3 | Mus musculus |
| 3 | Therefore, here, we examined TCDD-induced alterations in the gut microbiome, host liver transcriptome, and glucose tolerance in Fmo3+/+ and Fmo3-/- mice. | Polychlorinated Dibenzodioxins | flavin containing monooxygenase 3 | Mus musculus |
| 4 | Therefore, here, we examined TCDD-induced alterations in the gut microbiome, host liver transcriptome, and glucose tolerance in Fmo3+/+ and Fmo3-/- mice. | Polychlorinated Dibenzodioxins | flavin containing monooxygenase 3 | Mus musculus |
| 5 | Our results show that Fmo3 is a critical component of the transcriptional response to TCDD, impacting the gut microbiome, host liver transcriptome, and systemic glucose tolerance. | Polychlorinated Dibenzodioxins | flavin containing monooxygenase 3 | Mus musculus |