Title : Caspase-3 mediated switch therapy of self-triggered and long-acting prodrugs for metastatic TNBC.

Pub. Date : 2022 Jun

PMID : 35447298






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Here, we describe a tumoral caspase-3 mediated peptide-doxorubicin conjugates (PDC) switch therapy that adopts two different caspase-3 cleavable PDCs, RGDEVD-DOX (TPD1) and EMC-KGDEVD-DOX (MPD1), for targeting metastatic triple-negative breast cancer (mTNBC). Doxorubicin caspase 3 Homo sapiens
2 Here, we describe a tumoral caspase-3 mediated peptide-doxorubicin conjugates (PDC) switch therapy that adopts two different caspase-3 cleavable PDCs, RGDEVD-DOX (TPD1) and EMC-KGDEVD-DOX (MPD1), for targeting metastatic triple-negative breast cancer (mTNBC). Doxorubicin caspase 3 Homo sapiens