Pub. Date : 2022
PMID : 35444406
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | At the same time, we found that alcohol feeding promoted the phosphorylation of EGFR and ERK1/2, both of which were effectively inhibited by suramin (20 mg/kg). | Suramin | mitogen-activated protein kinase 3 | Mus musculus |
| 2 | In vitro, suramin or P2Y2R silencing effectively inhibited the phosphorylation of EGFR and ERK1/2, similar to the down-regulated effects of their corresponding inhibitors (EGFR inhibitor AG1478 and ERK1/2 inhibitor U0126) accompanied by reduced levels of TNF-alpha and IL-1beta compared to alcohol-induced AML-12 cell. | Suramin | mitogen-activated protein kinase 3 | Mus musculus |
| 3 | In vitro, suramin or P2Y2R silencing effectively inhibited the phosphorylation of EGFR and ERK1/2, similar to the down-regulated effects of their corresponding inhibitors (EGFR inhibitor AG1478 and ERK1/2 inhibitor U0126) accompanied by reduced levels of TNF-alpha and IL-1beta compared to alcohol-induced AML-12 cell. | Suramin | mitogen-activated protein kinase 3 | Mus musculus |